[Oh, having lost physical records of research is a difficult thing. Sholmes oft relies on his mind to pursue his interests, and for him, loss of information is no great thing since he expunges all he doesn't care from his own thought processes. But the scope of which she speaks sounds... grander than going about solving crimes strewn about London. Same appreciation for finding the truth, different application.

Even so, his advice, so simple, does not change. He heats his pipe again, leaning forward, puffing to draw it in.]

Do not give up, my dear. You will feel... unhappy, if you do.

[That, he knows.]

I should hope this is what your husband tells you, too.